Macrolides Inhibit Capsule Formation of Highly Virulent Cryptococcus gattii and Promote Innate Immune Susceptibility-Reference-Cited by-同舟云学术

Macrolides Inhibit Capsule Formation of Highly Virulent Cryptococcus gattii and Promote Innate Immune Susceptibility

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nakamura Shigeki¹,Ikeda-Dantsuji Yurika¹,Jin Lianjin¹,Higashi Yoshitsugu¹,Abe Masahiro¹,Inukai Tatsuya¹,Nagi Minoru¹,Urai Makoto²,Miyazaki Yoshitsugu¹

Affiliation:

1. Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan

2. Department of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Tokyo, Japan

Abstract

Cryptococcus gattii is a fungal pathogen, endemic in tropical and subtropical regions, the west coast of Canada, and the United States, that causes a potentially fatal infection in otherwise healthy individuals. Because the cryptococcal polysaccharide capsule is a leading virulence factor due to its resistance against innate immunity, the inhibition of capsule formation may be a promising new therapeutic strategy for C. gattii .

Funder

Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development

Japan Agency for Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02364-18

Reference44 articles.

1. Spread ofCryptococcus gattiiin British Columbia, Canada, and Detection in the Pacific Northwest, USA

2. Longitudinal clinical findings and outcome among patients with Cryptococcus gattii infection in British Columbia;Phillips P;Clin Infect Dis,2015