Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes-Reference-Cited by-同舟云学术

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Published:2019-04 Issue:4 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Wangchuk Phurpa¹,Shepherd Catherine¹,Constantinoiu Constantin²,Ryan Rachael Y. M.¹,Kouremenos Konstantinos A.³,Becker Luke¹,Jones Linda¹,Buitrago Geraldine¹,Giacomin Paul¹,Wilson David¹,Daly Norelle¹,McConville Malcolm J.³,Miles John J.¹,Loukas Alex¹

Affiliation:

1. Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia

2. College of Public Health, Medical and Veterinary Sciences, Centre for Biosecurity in Tropical Infectious Diseases, James Cook University, Townsville, Australia

3. Metabolomics Australia, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

Abstract

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrated that low-molecular-weight metabolites derived from both somatic extracts (LMWM-SE) and excretory-secretory products (LMWM-ESP) of the hookworm, Ancylostoma caninum , display anti-inflammatory properties.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00851-18

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3. Emerging trends of inflammatory bowel disease in Asia;Ng CS;Gastroenterol Hepatol (N Y),2016