Coxiella burnetii Isolates Cause Genogroup-Specific Virulence in Mouse and Guinea Pig Models of Acute Q Fever

Author:

Russell-Lodrigue K. E.12,Andoh M.1,Poels M. W. J.13,Shive H. R.2,Weeks B. R.2,Zhang G. Q.1,Tersteeg C.13,Masegi T.4,Hotta A.5,Yamaguchi T.5,Fukushi H.5,Hirai K.5,McMurray D. N.1,Samuel J. E.1

Affiliation:

1. Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, Texas

2. Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas

3. Institute of Life Sciences and Chemistry, Utrecht, The Netherlands

4. and Department of Pathogenetic Veterinary Science

5. Department of Applied Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan

Abstract

ABSTRACT Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii . Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and pathological responses to infection with phase I C. burnetii isolates from the following four genomic groups were evaluated in immunocompetent and immunocompromised mice and in guinea pig infection models: group I (Nine Mile, African, and Ohio), group IV (Priscilla and P), group V (G and S), and group VI (Dugway). Isolates from all of the groups produced disease in the SCID mouse model, and genogroup-consistent trends were noted in cytokine production in response to infection in the immunocompetent-mouse model. Guinea pigs developed severe acute disease when aerosol challenged with group I isolates, mild to moderate acute disease in response to group V isolates, and no acute disease when infected with group IV and VI isolates. C. burnetii isolates have a range of disease potentials; isolates within the same genomic group cause similar pathological responses, and there is a clear distinction in strain virulence between these genomic groups.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference54 articles.

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