Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice-Reference-Cited by-同舟云学术

Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Boehm Dylan T.¹²,Hall Jesse M.¹²,Wong Ting Y.¹²,DiVenere Andrea M.³,Sen-Kilic Emel¹²,Bevere Justin R.¹²,Bradford Shelby D.¹²,Blackwood Catherine B.¹²,Elkins Cody M.¹,DeRoos Katherine A.¹²,Gray Mary C.⁴,Cooper C. Garret²⁵,Varney Melinda E.¹²,Maynard Jennifer A.³^ORCID,Hewlett Erik L.⁴,Barbier Mariette¹²,Damron F. Heath¹²^ORCID

Affiliation:

1. Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA

2. Vaccine Development Center at West Virginia University Health Sciences Center, Morgantown, West Virginia, USA

3. Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA

4. Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA

5. Department of Medicine, Section of Infectious Diseases, West Virginia University, Morgantown, West Virginia, USA

Abstract

Bordetella pertussis is the primary causative agent of pertussis (whooping cough), which is a respiratory infection that leads to a violent cough and can be fatal in infants. There is a need to develop more effective vaccines because of the resurgence of cases of pertussis in the United States since the switch from the whole-cell pertussis vaccines (wP) to the acellular pertussis vaccines (aP; diphtheria-tetanus-acellular-pertussis vaccine/tetanus-diphtheria-pertussis vaccine).

Funder

NIAD

Jennifer Gossling Fellowship

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00857-17

Reference64 articles.

1. VACCINATION AGAINST WHOOPING COUGH

2. Mouse Protection Tests in the Study of Pertussis Vaccine