Affiliation:
1. Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112.
Abstract
It has been proposed that a decrease in the length of telomeres with the successive rounds of DNA replication that accompany mitotic division could play a causal role in the aging process. To investigate this possibility, telomeres from cells of the budding yeast Saccharomyces cerevisiae that varied in replicative age were examined. No change in the lengths of the telomeres was observed in cells that had completed up to 83% of the mean life span. We conclude that the length of the telomeres is not a contributing factor in the natural aging process in individual yeast cells.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference34 articles.
1. Ausubel F. M. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl (ed.). 1989. Current protocols in molecular biology vol. 1 and 2. Wiley-Interscience New York.
2. The molecular structure of centromeres and telomeres. Annu;Blackburn E. H.;Rev. Biochem.,1984
3. Molecular cloning of human telomeres in yeast;Brown W. R. A.;Nature (London),1989
4. CDC17: an essential gene that prevents telomere elongation in yeast;Carson M. J.;Cell,1985
5. Organization of DNA sequences and replication origins at yeast telomeres;Chan C. S. M.;Cell,1983
Cited by
87 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献