Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor

Author:

Shemer-Avni Y1,Wallach D1,Sarov I1

Affiliation:

1. Virology Unit, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.

Abstract

Purified human recombinant tumor necrosis factor (rTNF) alpha inhibited the growth of Chlamydia trachomatis (L2/434/Bu) in HEp-2 cell cultures. The inhibition of C. trachomatis yield could be achieved even when the rTNF alpha (200 ng/ml) was added up to 12 h after infection. The effect of rTNF alpha on chlamydial infection was synergistic with that of gamma interferon.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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