Validation of the BrockTB Stat-Pak Assay for Detection of Tuberculosis in Eurasian Badgers ( Meles meles ) and Influence of Disease Severity on Diagnostic Accuracy-Reference-Cited by-同舟云学术

Validation of the BrockTB Stat-Pak Assay for Detection of Tuberculosis in Eurasian Badgers ( Meles meles ) and Influence of Disease Severity on Diagnostic Accuracy

Published:2008-04 Issue:4 Volume:46 Page:1498-1500
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Chambers Mark A.¹,Crawshaw Tim²,Waterhouse Sue³,Delahay Richard⁴,Hewinson R. Glyn¹,Lyashchenko Konstantin P.⁵

Affiliation:

1. TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Surrey KT15 3NB, United Kingdom

2. Veterinary Laboratories Agency Starcross, Staplake Mount, Exeter, Devon EX6 8PE, United Kingdom

3. Veterinary Laboratories Agency Langford, Bristol BS40 5DX, United Kingdom

4. Central Science Laboratory, Sand Hutton, York YO4 1LZ, United Kingdom

5. Chembio Diagnostic Systems, Inc., Medford, New York 11763

Abstract

ABSTRACT A lateral-flow immunoassay (BrockTB Stat-Pak) for detecting tuberculosis in Eurasian badgers was 49% sensitive and 93% specific against culture for M. bovis ( n = 1,464) at necropsy. However, the sensitivity was significantly higher (66 to 78%) in animals with more severe tuberculosis, indicating that the BrockTB Stat-Pak may be useful for the detection of badgers with the greatest risk of transmitting disease.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02117-07

Reference17 articles.

1. Chambers, M. A., W. A. Pressling, C. L. Cheeseman, R. S. Clifton-Hadley, and R. G. Hewinson. 2002. Value of existing serological tests for identifying badgers that shed Mycobacterium bovis. Vet. Microbiol.86:183-189.

2. Clifton-Hadley, R. S., A. R. Sayers, and M. P. Stock. 1995. Evaluation of an ELISA for Mycobacterium bovis infection in badgers (Meles meles). Vet. Rec.137:555-558.

3. Clifton-Hadley, R. S., J. W. Wilesmith, and F. A. Stuart. 1993. Mycobacterium bovis in the European badger (Meles meles): epidemiological findings in tuberculous badgers from a naturally infected population. Epidemiol. Infect.111:9-19.

4. Corner, L. A. 2006. The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: how to assess the risk. Vet. Microbiol.112:303-312.

5. Tuberculosis

Cited by 62 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Metabolomic changes in the peripheral blood of wild trapped badgers correlate with bovine tuberculosis (Mycobacterium bovis) infection status;2023-09-08

2. Seroconversion against antigen MPB83 in badgers (Meles meles) vaccinated with multiple doses of BCG strain Sofia;Research in Veterinary Science;2022-12

3. Experimental Infection of Captive Red Foxes (Vulpes vulpes) with Mycobacterium bovis;Microorganisms;2022-02-06

4. Bayesian Estimation of Diagnostic Accuracy of Three Diagnostic Tests for Bovine Tuberculosis in Egyptian Dairy Cattle Using Latent Class Models;Veterinary Sciences;2021-10-21

5. Serologic responses correlate with current but not future bacterial shedding in badgers naturally infected with Mycobacterium bovis;Transboundary and Emerging Diseases;2021-06-17