Extracellular accumulation of a new amino acid, O-2-hydroxypropylhomoserine, from 1,2-propanediol by flavobacterium rigense

Author:

Yamada S,Nabe K,Ujimaru T,Izuo N,Chibata M

Abstract

During an investigation of microorganisms utilizing petrochemicals, a strain identified as Flavobacterium rigense was found to accumulate a new amino acid in a medium containing 1,2-propanediol as the sole carbon source. Cultural conditions for the accumulation of the product were investigated, and as a result, the yield was increased to 2.8 mg/ml after a 5-day incubation in a medium containing 8% 1,2-propanediol. The pure amino acid was isolated, and its structure was investigated. Elemental analysis and infrared, nuclear magnetic resonance, and mass spectral analyses indicated that the amino acids is O-2-hydroxypropylhomoserine.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Reference14 articles.

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3. Harada T. 1975. Microbial production of unusual substances from ethylalcohol. (in Japanese) Hakkokyokaishi 33:248-356.

4. O-alkyl-L-homoserines: three new amino acids formed from alcohols by Corynebacterium ethanolaminophilum sp. nov;Harada T.;Biochem. Biophys. Res. Commun.,1967

5. 0-alkylhomoserine and methionine biosynthesis in Corynebacterium;Harada T.;J. Biochem.,1969

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