Affiliation:
1. Connaught Medical Research Laboratories, University of Toronto, Toronto, Ontario, Canada
Abstract
A study on skin cross-reactivity between stabilized
14
C-labeled mycobacterial antigens, namely tuberculin purified protein derivative (PPD; from
Mycobacterium tuberculosis
), PPD-A (
M. avium
), PPD-Y (
M. kansasii
), PPD-G (
M. scrofulaceum
), PPD-B (
M. intracellulare
), and PPD-F (
M. fortuitum
), has been carried out in groups of guinea pigs sensitized with one of the following heat-killed mycobacteria:
M. tuberculosis, M. avium, M. kansasii, M. scrofulaceum, M. intracellulare
, or
M. fortuitum
. For each type of sensitization, the average response for the corresponding PPD antigen was higher than the average response for any of the other antigens. However, the responses to the heterologous PPD antigens were not necessarily significantly different among themselves, and the significant differences of the heterologous PPD antigens were distributed differently according to the type of sensitization. Therefore,
14
C-PPD antigens skin cross-reacted in guinea pigs essentially in the same manner as reported by others for nonradioactive PPD antigens.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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5. Comparative study of 14C-labeled purified protein derivative from various mycobacteria. I. Preparation of 14C-purified protein derivative antigens and their adsorption to glass;Landi S.;Appl. Microbiol.,1970
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