Cation and Anion Channelrhodopsins: Sequence Motifs and Taxonomic Distribution

Author:

Govorunova Elena G.1,Sineshchekov Oleg A.1,Li Hai1ORCID,Wang Yumei1,Brown Leonid S.2,Palmateer Alyssa2,Melkonian Michael3,Cheng Shifeng4,Carpenter Eric5,Patterson Jordan5,Wong Gane K.-S.56,Spudich John L.1

Affiliation:

1. Center for Membrane Biology, Department of Biochemistry & Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas, USA

2. Department of Physics and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario, Canada

3. Max Planck Institute for Plant Breeding Research, Integrative Bioinformatics, Cologne, Germany

4. Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China

5. Departments of Biological Sciences and of Medicine, University of Alberta, Edmonton, Alberta, Canada

6. Beijing Genomics Institute—Shenzhen, Shenzhen, China

Abstract

Channelrhodopsins are widely used in neuroscience and cardiology as research tools and are considered prospective therapeutics, but their natural diversity and mechanisms remain poorly characterized. Genomic and metagenomic sequencing projects are producing an ever-increasing wealth of data, whereas biophysical characterization of the encoded proteins lags behind.

Funder

HHS | National Institutes of Health

Welch Foundation

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

CAAS | Agricultural Science and Technology Innovation Program

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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