External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole-Reference-Cited by-同舟云学术

External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wu Yi Shuan S.¹^ORCID,Cohen-Wolkowiez Michael²³,Hornik Christoph P.²³,Gerhart Jacqueline G.¹,Autmizguine Julie⁴⁵,Cobbaert Marjan²,Gonzalez Daniel¹^ORCID

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Duke Clinical Research Institute, Durham, North Carolina, USA

3. Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

4. Research Center, CHU Sainte-Justine, Montréal, Quebec, Canada

5. Department of Pharmacology and Physiology, Université de Montréal, Montreal, Quebec, Canada

Abstract

The antibiotic combination trimethoprim (TMP)-sulfamethoxazole (SMX) has a broad spectrum of activity and is used for the treatment of numerous infections, but pediatric pharmacokinetic (PK) data are limited. We previously published population PK (popPK) models of oral TMP-SMX in pediatric patients based on sparse opportunistically collected data (POPS study) (J.

Funder

Nuventra Pharma Sciences

American Foundation for Pharmaceutical Education

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02149-20

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