Novel Variant ( bla VIM-4 ) of the Metallo-β-Lactamase Gene bla VIM-1 in a Clinical Strain of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Novel Variant ( bla VIM-4 ) of the Metallo-β-Lactamase Gene bla VIM-1 in a Clinical Strain of Pseudomonas aeruginosa

Published:2002-12 Issue:12 Volume:46 Page:4026-4028
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pournaras Spyros¹,Tsakris Athanassios²,Maniati Maria¹,Tzouvelekis Leonidas S.³,Maniatis Antonios N.¹

Affiliation:

1. Department of Medical Microbiology, University of Thessaly, Larissa

2. Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki

3. Department of Microbiology, Medical School, University of Athens, Athens, Greece

Abstract

ABSTRACT A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla VIM-4 , a novel variant of bla VIM-1 , with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.12.4026-4028.2002

Reference19 articles.

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