Penicillin-Binding Protein 1A, 2B, and 2X Alterations in Canadian Isolates of Penicillin-Resistant Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Penicillin-Binding Protein 1A, 2B, and 2X Alterations in Canadian Isolates of Penicillin-Resistant Streptococcus pneumoniae

Published:2002-10 Issue:10 Volume:46 Page:3261-3264
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nichol Kimberly A.¹²,Zhanel George G.¹³⁴²,Hoban Daryl J.¹²

Affiliation:

1. Department of Medical Microbiology, Faculty of Medicine

2. Clinical Microbiology, Health Sciences Centre, Winnipeg, Manitoba R3A 1R9, Canada

3. Faculty of Pharmacy, University of Manitoba

4. Departments of Medicine

Abstract

ABSTRACT Alterations within the penicillin-binding domain of penicillin-binding protein (PBP) genes pbp1a , pbp2b , and pbp2x were determined for 15 Canadian isolates of Streptococcus pneumoniae . All penicillin-nonsusceptible S. pneumoniae isolates showed a variety of PBP 2X substitutions and contained a Thr445-Ala change after the PBP 2B SSN motif. Only isolates for which penicillin MICs were ≥0.5 μg/ml had PBP 1A alterations near the STMK and SRN motifs. Sequence analysis revealed identical PBP 1A, PBP 2B, and PBP 2X substitution patterns among all isolates for which penicillin MICs were ≥1 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.10.3261-3264.2002

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