Efficacy of Linezolid against Methicillin-Resistant or Vancomycin-Insensitive Staphylococcus aureus in a Model of Hematogenous Pulmonary Infection-Reference-Cited by-同舟云学术

Efficacy of Linezolid against Methicillin-Resistant or Vancomycin-Insensitive Staphylococcus aureus in a Model of Hematogenous Pulmonary Infection

Published:2002-10 Issue:10 Volume:46 Page:3288-3291
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yanagihara Katsunori¹²,Kaneko Yukihiro¹,Sawai Toyomitsu¹,Miyazaki Yoshitsugu¹,Tsukamoto Kazuhiro¹²,Hirakata Yoichi¹,Tomono Kazunori¹,Kadota Jun-Ichi¹,Tashiro Takayoshi¹,Murata Ikuo¹²,Kohno Shigeru¹³

Affiliation:

1. Second Department of Internal Medicine

2. Department of Pharmacotherapeutics, Nagasaki University Graduate School of Pharmaceutical Sciences

3. Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan

Abstract

ABSTRACT We investigated the activities of linezolid, vancomycin, and teicoplanin in a murine model of hematogenous pulmonary infection with Staphylococcus aureus . Our results demonstrate that linezolid clearly reduced bacterial numbers in the methicillin-resistant S. aureus hematogenous infection model and significantly improved the survival rate of immunocompromised mice infected with vancomycin-insensitive S. aureus compared with vancomycin and teicoplanin. The pharmacokinetic profiles also reflected the effectiveness of linezolid.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.10.3288-3291.2002

Reference9 articles.

1. Chien, J. W., M. L. Kucia, and R. A. Salata. 2000. Use of linezolid, an oxazolidinone in the treatment of multidrug-resistant gram-positive bacterial infections. Clin. Infect. Dis.30:146-151.

2. Craig W. A. 1997. Postantibiotic effect and the dosing of macrolides azalides and streptogramins p. 27-38. In S. H. Zinner L. S. Young J. F. Acar and H. C. Neu (ed.) Expanding indications for the new macrolides azalides streptogramins. Marcel Dekker New York N.Y.

3. Efficacy of Linezolid in Treatment of Experimental Endocarditis Caused by Methicillin-Resistant Staphylococcus aureus

4. Hiramatsu, K., H. Hanaki, T. Ino, K. Yabuta, T. Oguri, and F. C. Tenover. 1997. A methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J. Antimicrob. Chemother.40:135-146.

5. Peng, G. W., R. P. Stryd, S. Murata, M. Igarashi, K. Chiba, H. Aoyama, M. Aoyama, T. Zenki, and N. Ozawa. 1999. Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography. J. Pharm. Biomed. Anal.20:65-73.

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