Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses-Reference-Cited by-同舟云学术

Naturally Occurring Human Monoclonal Antibodies Neutralize both 1918 and 2009 Pandemic Influenza A (H1N1) Viruses

Published:2010-03-15 Issue:6 Volume:84 Page:3127-3130
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Krause Jens C.¹,Tumpey Terrence M.²,Huffman Chelsey J.¹,McGraw Patricia A.¹,Pearce Melissa B.²,Tsibane Tshidi³,Hai Rong³,Basler Christopher F.³,Crowe James E.¹

Affiliation:

1. Departments of Pediatrics and of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232

2. Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

3. Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029

Abstract

ABSTRACT The 2009 pandemic influenza A (H1N1) virus exhibits hemagglutinin protein sequence homology with the 1918 pandemic influenza virus. We found that human monoclonal antibodies recognized the Sa antigenic site on the head domains of both 1918 and 2009 hemagglutinins, a site that is hypervariable due to immune selection. These antibodies exhibited high potency against the 2009 virus in vitro , and one exerted a marked therapeutic effect in vivo .

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02184-09

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