The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli-Reference-Cited by-同舟云学术

The IRE1α-XBP1 Signaling Axis Promotes Glycolytic Reprogramming in Response to Inflammatory Stimuli

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

English Bevin C.¹,Savage Hannah P.¹,Mahan Scott P.¹,Diaz-Ochoa Vladimir E.¹,Young Briana M.¹,Abuaita Basel H.²,Sule Gautam³,Knight Jason S.³,O’Riordan Mary X.²^ORCID,Bäumler Andreas J.¹^ORCID,Tsolis Renée M.¹^ORCID

Affiliation:

1. Department of Medical Microbiology and Immunology, University of California—Davis, Davis, California, USA

2. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

3. Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

Abstract

The immune system must be able to tailor its response to different types of pathogens in order to eliminate them and protect the host. When confronted with bacterial pathogens, macrophages, frontline defenders in the immune system, switch to a glycolysis-driven metabolism to carry out their antibacterial functions.

Funder

Crohn's and Colitis Foundation

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

Lupus Research Alliance

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03068-22

Reference67 articles.