Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

Author:

Celegato Marta1,Sturlese Mattia2,Vasconcelos Costa Vivian3,Trevisan Marta1,Lallo Dias Angélica Samer4,Souza Passos Ingredy Beatriz3,Queiroz-Junior Celso Martins3,Messa Lorenzo1,Favaro Annagiulia2,Moro Stefano2,Teixeira Mauro Martins4,Loregian Arianna1ORCID,Mercorelli Beatrice1ORCID

Affiliation:

1. Department of Molecular Medicine, University of Padua, Padua, Italy

2. Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy

3. Departamento de Morfologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

4. Departamento de Bioquímica e Imunologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Abstract

More than one-third of the human population is at risk of infection by different mosquito-borne flaviviruses. Despite this, no specific antiviral drug is currently available.

Funder

University of Padua

INCT dengue MCT/CN

EU Funding within the MUR PNRR Extended Partnership Initiative on Emerging Infectious Diseases

Associazione Italiana per la Ricerca sul Cancro

Fondazione Cassa di Risparmio di Padova e Rovigo

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference57 articles.

1. Dengue infection

2. Global Epidemiology of Dengue Outbreaks in 1990–2015: A Systematic Review and Meta-Analysis

3. Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond

4. World Health Organization. 2022. Dengue and severe dengue. World Health Organization Geneva Switzerland. https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.

5. The continued threat of emerging flaviviruses

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