Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis-Reference-Cited by-同舟云学术

Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis

Published:2023-02-28 Issue:1 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rashid Rafi¹²,Nair Zeus Jaren²³⁴,Chia Dominic Ming Hao²⁴,Chong Kelvin Kian Long²⁴,Cazenave Gassiot Amaury⁵⁶,Morley Stewart A.⁷⁸,Allen Doug K.⁷⁸,Chen Swaine L.⁹¹⁰^ORCID,Chng Shu Sin²¹¹^ORCID,Wenk Markus R.⁵⁶,Kline Kimberly A.²⁴¹²^ORCID

Affiliation:

1. Integrative Sciences & Engineering Programme, National University of Singapore, Singapore

2. Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore

3. Interdisciplinary Graduate School, Nanyang Technological University, Singapore

4. School of Biological Sciences, Nanyang Technological University, Singapore

5. Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore

6. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

7. Donald Danforth Plant Science Center, St. Louis, Missouri, USA

8. USDA-ARS, Plant Genetics Research Institute, St. Louis, Missouri, USA

9. GERMS and Infectious Disease Group, Genome Institute of Singapore, Singapore

10. Division of Infectious Diseases, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

11. Department of Chemistry, National University of Singapore, Singapore

12. Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

Abstract

The cell membrane plays a pivotal role in protecting bacteria against external threats, such as antibiotics. Cationic phospholipids such as lysyl-phosphatidyglycerol (L-PG) resist the action of cationic antimicrobial peptides through electrostatic repulsion.

Funder

Agency for Science, Technology and Research

MOH | National Medical Research Council

Ministry of Education - Singapore

Ministry of Health - Singapore

National Research Foundation Singapore

National Science Foundation

USDA | Agricultural Research Service

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03073-22

Reference57 articles.

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3. Biofilm-associated infection by enterococci

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5. The co-evolution of host cationic antimicrobial peptides and microbial resistance

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