Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rajavel Malligarjunan¹,Kumar Vijay¹^ORCID,Nguyen Ha¹,Wyatt Jacob¹,Marshall Steven H.²,Papp-Wallace Krisztina M.²³⁴^ORCID,Deshpande Prasad⁵,Bhavsar Satish⁵,Yeole Ravindra⁵,Bhagwat Sachin⁵,Patel Mahesh⁵,Bonomo Robert A.¹²³⁴⁶^ORCID,van den Akker Focco¹^ORCID

Affiliation:

1. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

2. Louis Stokes Cleveland Veteran’s Affairs Medical Center Research Service, Cleveland, Ohio, USA

3. Case Western Reserve University, Department of Medicine, Cleveland, Ohio, USA

4. Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA

5. Wockhardt Research Centre, Aurangabad, India

6. Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

Wockhardt

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03058-20

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