Escherichia coli-Derived Outer Membrane Vesicles Relay Inflammatory Responses to Macrophage-Derived Exosomes

Author:

Imamiya Risa1,Shinohara Akari2,Yakura Daisuke3,Yamaguchi Takehiro4,Ueda Koji5,Oguro Ami6,Minamiyama Yukiko2,Ichikawa Hiroshi3,Horiguchi Yasuhiko7ORCID,Osada-Oka Mayuko2ORCID

Affiliation:

1. Food Hygiene and Environmental Health, Faculty of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

2. Food Hygiene and Environmental Health, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

3. Department of Medical System Protective Health and Medicine Laboratory, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Japan

4. Department of Pharmacology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan

5. Project for Realization of Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan

6. Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

7. Department of Molecular Bacteriology, Research Institute of Microbial Diseases, Osaka University, Suita, Japan

Abstract

Recently, extracellular membrane vesicles (EVs) were regarded as drivers that carry cargo such as proteins, lipids, metabolites, RNA, and DNA for intracellular signaling transduction. Mammalian cells release various types of EVs, including microvesicles shed from the plasma membrane, exosomes from endosomes, apoptotic bodies, and others.

Funder

JSPS KAKEN

OU | Research Institute for Microbial Diseases, Osaka University

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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