IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency-Reference-Cited by-同舟云学术

IFI16 Partners with KAP1 to Maintain Epstein-Barr Virus Latency

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Xu Huanzhou¹,Li Xiaofan¹,Rousseau Beth A.¹,Akinyemi Ibukun A.²,Frey Tiffany R.²,Zhou Kevin¹,Droske Lauren E.¹,Mitchell Jennifer A.²,McIntosh Michael T.²³,Bhaduri-McIntosh Sumita¹³^ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

2. Child Health Research Institute, Department of Pediatrics, University of Florida, Gainesville, Florida, USA

3. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA

Abstract

The interferon-gamma inducible protein 16 (IFI16) is a nuclear DNA sensor that mediates antiviral responses by activating the inflammasome, triggering an interferon response, and silencing lytic genes of herpesviruses. The last, which helps maintain latency of the oncoherpesvirus Epstein-Barr virus (EBV), is accomplished via H3K9me3 heterochromatinization through unknown mechanisms.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Dental and Craniofacial Research

U.S. Department of Homeland Security

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01028-22

Reference48 articles.

1. The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication