Cathelicidin CATH-B1 Inhibits Pseudorabies Virus Infection via Direct Interaction and TLR4/JNK/IRF3-Mediated Interferon Activation-Reference-Cited by-同舟云学术

Cathelicidin CATH-B1 Inhibits Pseudorabies Virus Infection via Direct Interaction and TLR4/JNK/IRF3-Mediated Interferon Activation

Published:2023-07-27 Issue:7 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ye Chao¹^ORCID,Wan Chao¹,Chen Jing¹,Li Gang¹,Li Yixuan¹,Wang Yue¹,Tao Qi¹,Peng Lianci¹,Fang Rendong¹²³

Affiliation:

1. Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing, China

2. National Center of Technology Innovation for Pigs, Chongqing, China

3. Immunology Research Center, Medical Research Institute, Southwest University, Chongqing, China

Abstract

Although the antiviral activity of cathelicidins could be explained by direct interfering with the viral infection and regulating host antiviral response, the specific mechanism of cathelicidins regulating host antiviral response and interfering with pseudorabies virus (PRV) infection remains elusive. In this study, we investigated the multiple roles of cathelicidin CATH-B1 against PRV infection.

Funder

MOST | National Key Research and Development Program of China

MOE | Fundamental Research Funds for the Central Universities

MOST | National Natural Science Foundation of China

National Center of Technology Innovation for Pigs

The Chongqing Pig Industry Technology System

The Foundation for Innovation Research Group in Chongqing Universities

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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