Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections-Reference-Cited by-同舟云学术

Passive Immunization with a Single Monoclonal Neutralizing Antibody Protects against Cutaneous and Mucosal Mouse Papillomavirus Infections

Published:2022-08-24 Issue:16 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Brendle Sarah A.¹²,Li Jingwei¹²,Cladel Nancy M.¹²,Balogh Karla K.¹²,Booth Jennifer³,Shearer Debra A.¹²,Walter Vonn⁴⁵,Lu Song²,Christensen Neil D.¹²⁶,Covington Danielle³,DeBroff Jake¹²,Milici Janice⁶,Zhu Yusheng²⁷,Viscidi Raphael⁸⁹,Hu Jiafen¹²^ORCID

Affiliation:

1. The Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

2. Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

3. Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

4. Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

5. Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

6. Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

7. Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

8. Department of Pediatrics, The Johns Hopkins University, Baltimore, Maryland, USA

9. Department of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA

Abstract

This is the first study testing a single monoclonal neutralizing antibody (MPV.A4) by passive immunization against papillomavirus infections at both cutaneous and mucosal sites in the same host in the mouse papillomavirus model. We demonstrated that MPV.A4 administered before viral inoculation can protect both male and female athymic mice against MmuPV1 infections at cutaneous and mucosal sites.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Dental and Craniofacial Research

HHS | NIH | National Cancer Institute

The Jake Gittlen Memorial Golf Tournament

Penn State Cancer Institute program project development award by highmark community health reinvestiment fund

Pathology Department research fund

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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