Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1-Reference-Cited by-同舟云学术

Human MX2/MxB: a Potent Interferon-Induced Postentry Inhibitor of Herpesviruses and HIV-1

Published:2018-12-15 Issue:24 Volume:92 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Staeheli Peter¹²,Haller Otto¹²³

Affiliation:

1. Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany

2. Medical Faculty, University of Freiburg, Freiburg, Germany

3. Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

Abstract

Interferons limit viral replication by inducing intracellular restriction factors, such as the GTPase MxB (also designated MX2), which inhibits HIV-1 and, as recently shown, herpesviruses. Inhibition of these viruses occurs at ill-defined steps after viral entry and requires formation of MxB dimers or oligomers, but GTP hydrolysis is needed only for blocking herpesviruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00709-18

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