Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli

Author:

Kapoor Indu1,Emam Elhassan Ali Fathi1,Shaw Abhirup1,Varshney Umesh12

Affiliation:

1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

2. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

Abstract

Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, is known for its critical role in homeostasis of cellular nucleotide pools. However, NDK has now emerged as a molecule with pleiotropic effects in DNA repair, protein phosphorylation, gene expression, tumor metastasis, development, and pathogen virulence and persistence inside the host. In this study, we reveal an unexpected role of NDK in genome instability because of its activity in converting 8-O-dGDP to 8-O-dGTP. This observation has important consequences in escalating A-to-C mutations in Escherichia coli . The severity of NDK in enhancing these mutations may be higher in the organisms challenged with high oxidative stress, which promotes 8-O-dGDP/8-O-dGTP production.

Funder

Department of Biotechnology , Ministry of Science and Technology

DST | Science and Engineering Research Board

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference45 articles.

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