Assessment of the Effects of Combination Therapy with Ciprofloxacin and Fenbufen on the Central Nervous Systems of Healthy Volunteers by Quantitative Electroencephalography-Reference-Cited by-同舟云学术

Assessment of the Effects of Combination Therapy with Ciprofloxacin and Fenbufen on the Central Nervous Systems of Healthy Volunteers by Quantitative Electroencephalography

Published:1998-05 Issue:5 Volume:42 Page:1256-1258
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kamali F.¹,Ashton C. H.²,Marsh V. R.²,Cox J.¹

Affiliation:

1. Wolfson Unit of Clinical Pharmacology, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom

2. 2 and Department of Psychiatry, University of Newcastle, Newcastle upon Tyne NE2 4HH, United Kingdom

Abstract

ABSTRACT The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability. When ciprofloxacin was administered in combination with fenbufen, none of the EEG parameters or VAS ratings measured were significantly different from those measured when the drugs were administered alone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.5.1256

Reference21 articles.

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