The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae-Reference-Cited by-同舟云学术

The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae

Published:2020-10-27 Issue:5 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Walker Kimberly A.¹^ORCID,Treat Logan P.¹,Sepúlveda Victoria E.¹^ORCID,Miller Virginia L.¹²^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

2. Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

Abstract

Capsule is a critical virulence factor in Klebsiella pneumoniae , in both antibiotic-resistant classical strains and hypervirulent strains. Hypervirulent strains usually have a hypermucoviscosity (HMV) phenotype that contributes to their heightened virulence capacity, but the production of HMV is not understood. The transcriptional regulator RmpA is required for HMV and also activates capsule gene expression, leading to the assumption that HMV is caused by hyperproduction of capsule. We have identified a new gene ( rmpD ) required for HMV but not for capsule production. This distinction between HMV and capsule production will promote a better understanding of the mechanisms of hypervirulence, which is in great need given the alarming increase in clinical isolates with both drug resistance and hypervirulence traits.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01750-20

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