A Stenotrophomonas maltophilia TetR-Like Transcriptional Regulator Involved in Fatty Acid Metabolism Is Controlled by Quorum Sensing Signals

Author:

Coves Xavier12,Bravo Marc12,Huedo Pol1,Conchillo-Solé Òscar12,Gómez Andromeda-Celeste12,Esteve-Codina Anna34,Dabad Marc3,Gut Marta3,Daura Xavier156,Yero Daniel12ORCID,Gibert Isidre12ORCID

Affiliation:

1. Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain

2. Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain

3. CNAG-CRG, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain

4. Universitat Pompeu Fabra (UPF), Barcelona, Spain

5. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain

6. Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Cerdanyola del Vallès, Spain

Abstract

The quorum sensing system in Stenotrophomonas maltophilia , in addition to coordinating the bacterial population, controls virulence-associated phenotypes, such as biofilm formation, motility, protease production, and antibiotic resistance mechanisms. Biofilm formation is frequently associated with the persistence and chronic nature of nosocomial infections.

Funder

Ministerio de Ciencia e Innovación

Government of Catalonia | Agència de Gestió d'Ajuts Universitaris i de Recerca

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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