Varicella-zoster virus vaccine DNA differs from the parental virus DNA-Reference-Cited by-同舟云学术

Varicella-zoster virus vaccine DNA differs from the parental virus DNA

Published:1981-10 Issue:1 Volume:40 Page:314-318
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ecker J R,Hyman R W

Abstract

The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.40.1.314-318.1981

Reference27 articles.

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