N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle-Reference-Cited by-同舟云学术

N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle

Published:2023-02-16 Issue:2 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sow Aïssatou Aïcha¹,Pahmeier Felix²^ORCID,Ayotte Yann¹,Anton Anaïs¹,Mazeaud Clément¹,Charpentier Tania¹,Angelo Léna¹,Woo Simon¹,Cerikan Berati²,Falzarano Darryl³⁴^ORCID,Abrahamyan Levon⁵^ORCID,Lamarre Alain¹,Labonté Patrick¹,Cortese Mirko²⁶,Bartenschlager Ralf²⁷^ORCID,LaPlante Steven R.¹,Chatel-Chaix Laurent¹⁸⁹^ORCID

Affiliation:

1. Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Quebec, Canada

2. Department of Infectious Diseases, Molecular Virology, Center for Integrative Infectious Disease Research (CIID), Heidelberg University, Heidelberg, Germany

3. Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada

4. Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

5. Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, Quebec, Canada

6. Telethon Institute of Genetics and Medicine, Naples, Italy

7. German Center for Infection Research (DZIF), Heidelberg partner site, Heidelberg, Germany

8. Center of Excellence in Orphan Diseases Research-Foundation Courtois, Quebec, Canada

9. Réseau Intersectoriel de Recherche en Santé de l’Université du Québec, Quebec, Canada

Abstract

Dengue virus (DENV) is a Flavivirus that causes the most prevalent arthropod-borne viral disease. Clinical manifestation of DENV infection ranges from asymptomatic to severe symptoms that can lead to death.

Funder

Canadian Institutes of Health Research

Gouvernement du Canada | Canadian Institutes of Health Research

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01331-22

Reference36 articles.