The rel Gene Is Essential for In Vitro Growth of Staphylococcus aureus

Author:

Gentry Daniel1,Li Tong1,Rosenberg Martin1,McDevitt Damien1

Affiliation:

1. SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426

Abstract

ABSTRACT The stringent response in Staphylococcus aureus is mediated by the nucleotide guanosine pentaphosphate, whose synthesis is catalyzed by the product of the rel gene. We report here that the rel gene is essential for the in vitro growth of S. aureus , distinguishing it from all other bacteria tested for this requirement.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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4. Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci

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