Positive Correlation between Virulence of Pseudomonas aeruginosa Mutants in Mice and Insects-Reference-Cited by-同舟云学术

Positive Correlation between Virulence of Pseudomonas aeruginosa Mutants in Mice and Insects

Published:2000-07 Issue:13 Volume:182 Page:3843-3845
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Jander Georg¹,Rahme Laurence G.²,Ausubel Frederick M.¹

Affiliation:

1. Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital,1 and

2. Department of Surgery, Harvard Medical School, and Shriner's Burns Institute, Massachusetts General Hospital,2 Boston, Massachusetts 02114

Abstract

ABSTRACT Strain PA14, a human clinical isolate of Pseudomonas aeruginosa , is pathogenic in mice and insects ( Galleria mellonella ). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa .

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.182.13.3843-3845.2000

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