Identification of Brucella abortus OxyR and Its Role in Control of Catalase Expression

Author:

Kim Jeong-a1,Mayfield John1

Affiliation:

1. Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011

Abstract

ABSTRACT We report the cloning and sequencing of the Brucella abortus oxyR homolog and provide evidence that the transcription product of this gene binds to the B. abortus catalase promoter region. A gene replacement/deletion Brucella oxyR mutant exhibits increased sensitivity to prolonged exposure to H 2 O 2 and is unable to adapt to H 2 O 2 in the environment.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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5. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins;Christman M. F.;Proc. Natl. Acad. Sci. USA,1989

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