Synechocystis Strain PCC 6803 cya 2, a Prokaryotic Gene That Encodes a Guanylyl Cyclase-Reference-Cited by-同舟云学术

Synechocystis Strain PCC 6803 cya 2, a Prokaryotic Gene That Encodes a Guanylyl Cyclase

Published:2000-07 Issue:13 Volume:182 Page:3839-3842
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Ochoa de Alda Jesús A. G.¹,Ajlani Ghada²,Houmard Jean¹

Affiliation:

1. Dynamique des Membranes Végétales, Complexes Protéines-Pigments, CNRS UMR8543, Ecole Normale Supérieure, 75230 Paris Cedex 05, France,1 and

2. CNRS URA2096, DBCM/SBPM, CEA Saclay, 91191 Gif sur Yvette Cedex, France2

Abstract

ABSTRACT Synechocystis strain PCC 6803 exhibits similar levels of cyclic AMP (cAMP) and cyclic GMP (cGMP). A thorough analysis of its genome showed that Cya2 (Sll0646) has all the sequence determinants required in terms of activity and purine specificity for being a guanylyl cyclase. Insertional mutagenesis of cya2 caused a marked reduction in cGMP content without altering the cAMP content. Thus, Cya2 represents the first example of a prokaryotic guanylyl cyclase.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.182.13.3839-3842.2000

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