Effects of Amino Acid Substitutions at Conserved and Acidic Residues within Region 1.1 of Escherichia coli ς 70-Reference-Cited by-同舟云学术

Effects of Amino Acid Substitutions at Conserved and Acidic Residues within Region 1.1 of Escherichia coli ς 70

Published:2000-01 Issue:1 Volume:182 Page:221-224
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bowers Christina Wilson¹,McCracken Andrea¹,Dombroski Alicia J.¹

Affiliation:

1. Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, Houston, Texas 77030

Abstract

ABSTRACT Amino acid substitutions in Escherichia coli ς 70 were generated and characterized in an analysis of the role of region 1.1 in transcription initiation. Several acidic and conserved residues are tolerant of substitution. However, replacement of aspartic acid 61 with alanine results in inactivity caused by structural and functional thermolability.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.182.1.221-224.2000

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