Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales-Reference-Cited by-同舟云学术

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales

Published:2021-05-18 Issue:6 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zalacain Magdalena¹,Lozano Clarisse¹,Llanos Agustina¹,Sprynski Nicolas¹,Valmont Thomas²,De Piano Cyntia²,Davies David¹,Leiris Simon¹,Sable Carole¹,Ledoux Adeline¹,Morrissey Ian²,Lemonnier Marc¹,Everett Martin¹^ORCID

Affiliation:

1. Antabio SAS, Labège, France

2. IHMA Europe Sàrl, Monthey, Switzerland

Abstract

The global dissemination of metallo-β-lactamase (MBL)-producing carbapenem-resistant Enterobacterales (CRE) is a serious public health concern. Specifically, NDM (New Delhi MBL) has been a major cause of carbapenem therapy failures in recent years, particularly as effective treatments for serine-β-lactamase (SBL)-producing Enterobacterales are now commercially available.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00203-21

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