Author:
Singh Pushpendra,Busso Philippe,Paniz-Mondolfi Alberto,Aranzazu Nacarid,Monot Marc,Honore Nadine,de Faria Fernandes Belone Andrea,Virmond Marcos,Villarreal-Olaya Maria Esther,Rivas Carlos,Cole Stewart T.
Abstract
ABSTRACTPossible drug resistance inMycobacterium lepraestrains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference28 articles.
1. Molecular detection of rifampin and ofloxacin resistance for patients who experience relapse of multibacillary leprosy;Cambau;Clin. Infect. Dis,2002
2. Dihydropteroate synthase mutations in the folP1 gene predict dapsone resistance in relapsed cases of leprosy;Cambau;Clin. Infect. Dis,2006
3. Multidrug-resistance to dapsone, rifampicin, and ofloxacin in Mycobacterium leprae;Cambau;Lancet,1997
4. Primary dapsone resistance in Cebu, The Philippines; cause for concern;dela Cruz;Int. J. Lepr. Other Mycobact. Dis,1996
5. Drug resistant Mycobacterium leprae—results of mouse footpad studies from a laboratory in south India;Ebenezer;Indian J. Lepr,2002
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