Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa-Reference-Cited by-同舟云学术

Plasmodium falciparum Isolates with Increased pfmdr1 Copy Number Circulate in West Africa

Published:2010-07 Issue:7 Volume:54 Page:3049-3051
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Witkowski Benoit¹²,Nicolau Marie-Laure¹²,Soh Patrice Njomnang¹²,Iriart Xavier¹³,Menard Sandie¹³,Alvarez Muriel⁴,Marchou Bruno⁴,Magnaval Jean-François¹,Benoit-Vical Françoise¹²,Berry Antoine¹³

Affiliation:

1. Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, and Faculté de Médecine de Rangueil, Université de Toulouse III, Toulouse, France

2. Laboratoire de Chimie de Coordination, CNRS, UPR8241, and Université de Toulouse III, Toulouse, France

3. UMR3 MD-UM-UPS, Université Paul Sabatier Toulouse III, Toulouse, France

4. Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Toulouse, Toulouse, France

Abstract

ABSTRACT Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as possible.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00209-10

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