Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity-Reference-Cited by-同舟云学术

Discovery of the Pseudomonas Polyyne Protegencin by a Phylogeny-Guided Study of Polyyne Biosynthetic Gene Cluster Diversity

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mullins Alex J.¹^ORCID,Webster Gordon¹^ORCID,Kim Hak Joong²^ORCID,Zhao Jinlian³,Petrova Yoana D.¹^ORCID,Ramming Christina E.³,Jenner Matthew³⁴^ORCID,Murray James A. H.⁵^ORCID,Connor Thomas R.¹^ORCID,Hertweck Christian²⁶^ORCID,Challis Gregory L.³⁴⁷⁸^ORCID,Mahenthiralingam Eshwar¹^ORCID

Affiliation:

1. Microbiomes, Microbes and Informatics Group, Organisms and Environment Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom

2. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

3. Department of Chemistry, University of Warwick, Coventry, United Kingdom

4. Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, United Kingdom

5. Molecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, United Kingdom

6. Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany

7. Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

8. ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton, Victoria, Australia

Abstract

Natural products bearing alkyne (triple carbon bond) or polyyne (multiple alternating single and triple carbon bonds) moieties exhibit a broad range of important biological activities. Polyyne metabolites have been implicated in important ecological roles such as cepacin mediating biological control of plant pathogens and caryoynencin protecting Lagriinae beetle eggs against pathogenic fungi.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

UKRI | Medical Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00715-21

Reference38 articles.

1. Alkynyl-Containing Peptides of Marine Origin: A Review