Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris-Reference-Cited by-同舟云学术

Transcriptomics and Phenotyping Define Genetic Signatures Associated with Echinocandin Resistance in Candida auris

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Jenull Sabrina¹²,Shivarathri Raju³⁴,Tsymala Irina¹,Penninger Philipp¹,Trinh Phan-Canh¹^ORCID,Nogueira Filomena¹⁵,Chauhan Manju³⁴,Singh Ashutosh⁶,Petryshyn Andriy¹,Stoiber Anton¹,Chowdhary Anuradha⁶^ORCID,Chauhan Neeraj³⁴^ORCID,Kuchler Karl¹^ORCID

Affiliation:

1. Department of Medical Biochemistry, Max Perutz Labs Vienna, Medical University of Vienna, Campus Vienna Biocenter, Vienna, Austria

2. Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine, Vienna, Austria

3. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA

4. Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA

5. CCRI-St. Anna Children’s Cancer Research Institute, Vienna, Austria

6. National Reference Laboratory for Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

Abstract

The surge in antimicrobial drug resistance in some bacterial and fungal pathogens constitutes a significant challenge to health care facilities. The emerging human fungal pathogen Candida auris has been particularly concerning, as isolates can display pan-antifungal resistance traits against all drugs, including echinocandins.

Funder

Austrian Science Fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00799-22

Reference107 articles.

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