A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP-Reference-Cited by-同舟云学术

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Shahsavari Negar¹,Wang Boyuan²³,Imai Yu¹,Mori Miho¹,Son Sangkeun¹,Liang Libang¹,Böhringer Nils⁴⁵,Manuse Sylvie¹,Gates Michael F.¹,Morrissette Madeleine¹,Corsetti Rachel¹,Espinoza Josh L.⁶,Dupont Chris L.⁶,Laub Michael T.³⁷^ORCID,Lewis Kim¹^ORCID

Affiliation:

1. Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, Massachusetts, USA

2. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

4. Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen, Germany

5. German Center of Infection Research (DZIF), Partner Site Gießen-Marburg-Langen, Gießen, Germany

6. J. Craig Venture Institute, La Jolla, California, USA

7. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

Abstract

Drug-resistant Gram-negative bacteria have become the major problem driving the antimicrobial resistance crisis. Searching outside the overmined actinomycetes, we focused on Photorhabdus , gut symbionts of enthomopathogenic nematodes that carry up to 40 biosynthetic gene clusters coding for secondary metabolites.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00700-22

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