A Biological Signature for the Inhibition of Outer Membrane Lipoprotein Biogenesis-Reference-Cited by-同舟云学术

A Biological Signature for the Inhibition of Outer Membrane Lipoprotein Biogenesis

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lehman Kelly M.¹²³⁴,Smith Hannah C.¹²³⁴,Grabowicz Marcin²³⁴^ORCID

Affiliation:

1. Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, USA

2. Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

3. Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

4. Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

Gram-negative bacteria have an outer membrane, which acts as a protective barrier and excludes many antibiotics. The limited number of antibiotics active against Gram-negative bacteria, along with rising rates of antibiotic resistance, highlights the need for efficient antibiotic discovery efforts.

Funder

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00757-22

Reference83 articles.

1. The Science of Antibiotic Discovery