Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

Author:

Mathieu Cyrille123ORCID,Bovier Francesca T.124,Ferren Marion123,Lieberman Nicole A. P.5,Predella Camilla2,Lalande Alexandre3,Peddu Vikas5,Lin Michelle J.5,Addetia Amin5,Patel Achchhe6,Outlaw Victor7ORCID,Corneo Barbara6,Dorrello N. Valerio2,Briese Thomas89,Hardie Diana10,Horvat Branka3ORCID,Moscona Anne121112,Greninger Alexander L.5,Porotto Matteo124ORCID

Affiliation:

1. Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

2. Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

3. CIRI, Centre International de Recherche en Infectiologie, Team Immuno-Biology of Viral Infections, University of Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France

4. Department of Experimental Medicine, University of Study of Campania “Luigi Vanvitelli”, Naples, Italy

5. Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA

6. Stem Cell Core Facility, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

7. Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA

8. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USA

9. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA

10. Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa

11. Department of Microbiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

12. Department of Physiology and Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA

Abstract

Measles virus (MeV) infection can cause serious complications in immunocompromised individuals, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE), another severe central nervous system (CNS) complication, develop even in the face of a systemic immune response.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Neurological Disorders and Stroke

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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