Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites-Reference-Cited by-同舟云学术

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Mathews Emily S.¹,Jezewski Andrew J.¹²,Odom John Audrey R.¹³⁴^ORCID

Affiliation:

1. Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

3. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

4. Division of Infectious Disease, Department of Pediatrics, Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts. Protein prenylation is required during asexual replication of Plasmodium falciparum , and the canonical heat shock protein 40 protein (HSP40; PF3D7_1437900) is posttranslationally modified with a 15-carbon farnesyl isoprenyl group.

Funder

HHS | National Institutes of Health

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00760-21

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