Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density-Reference-Cited by-同舟云学术

Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Rattray Jennifer B.¹²^ORCID,Thomas Stephen A.¹²³,Wang Yifei¹²⁴^ORCID,Molotkova Evgeniya¹,Gurney James¹²,Varga John J.¹²^ORCID,Brown Sam P.¹²

Affiliation:

1. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

2. Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA

3. Graduate Program in Quantitative Biosciences (QBioS), Georgia Institute of Technology, Atlanta, Georgia, USA

4. The Institute for Data Engineering and Science (IDEaS), Georgia Institute of Technology, Atlanta, Georgia, USA

Abstract

Bacteria can be highly social, controlling collective behaviors via cell-cell communication mechanisms known as quorum sensing (QS). QS is now a large research field, yet a basic question remains unanswered: what is the environmental resolution of QS? The notion of a threshold, or “quorum,” separating coordinated ON and OFF states is a central dogma in QS, but recent studies have shown heterogeneous responses at a single cell scale.

Funder

National Science Foundation

Simons Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00745-22

Reference74 articles.

1. Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control