FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat-Reference-Cited by-同舟云学术

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Yang Xinyi¹,Zhao Xiaying¹,Zhu Yuqi¹,Shen Yinzhong²,Wang Yanan¹,Lu Panpan¹,Jiang Zhengtao¹,Pan Hanyu¹,Yang Jinlong¹,Xun Jingna¹²,Zhao Lin¹,Wang Jing¹,Liang Zhiming¹,Shen Xiaoting¹,Liang Yue¹,Lin Qinru¹,Liang Huitong¹,Jin Lu¹,Zhang Dengji¹,Liu Jun¹,Wang Bin¹,Jiang Shibo²,Xu Jianqing²,Wu Hao³,Lu Hongzhou²,Zhu Huanzhang¹^ORCID

Affiliation:

1. State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

2. Department of Infectious Disease, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, School of Basic Medical Sciences and Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

3. Center for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Fengtai District, Beijing, China

Abstract

The primary reason why AIDS cannot be completely cured is the existence of a latent HIV-1 reservoir. Currently, the facts of HIV-1 latency, including its establishment and maintenance, are incomplete.

Funder

National Natural Science Foundation of China

National Grand Program on Key infectious Disease

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00795-21

Reference52 articles.

1. An Integrated Overview of HIV-1 Latency

2. Latency reversal and viral clearance to cure HIV-1