Antimalarial Activity of a Synthetic Endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum Isolates from Gabon-Reference-Cited by-同舟云学术

Antimalarial Activity of a Synthetic Endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum Isolates from Gabon

Published:2006-04 Issue:4 Volume:50 Page:1535-1537
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kreidenweiss Andrea¹²,Mordmüller Benjamin¹²,Krishna Sanjeev¹³,Kremsner Peter G.¹²

Affiliation:

1. Medical Research Laboratory, Albert Schweitzer Hospital, Lambaréné, Gabon

2. Department of Parasitology, University of Tübingen, Germany

3. Division of Cellular and Molecular Medicine, Centre for Infection, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, Great Britain

Abstract

ABSTRACT OZ277 is a newly developed, fully synthetic endoperoxide antimalarial that we tested against field isolates from Gabon. A comparison of activities of OZ277 with artesunate, mefloquine, and chloroquine showed OZ277 to be highly active against all parasite isolates. Artesunate and mefloquine also showed potent antiparasitic activity, but all isolates were chloroquine resistant.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.50.4.1535-1537.2006

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