Abstract
The in vitro activity of ciprofloxacin, a quinolone-carboxylic acid derivative, was compared with those of norfloxacin, cefotaxime, cephalexin, ceftazidime, moxalactam, amoxicillin, and methicillin and other agents, as appropriate. The MICs of ciprofloxacin for 90% of members of the family Enterobacteriaceae and for Pseudomonas aeruginosa, Neisseria spp., and Bacteroides fragilis were between 0.005 and 0.8 micrograms/ml, whereas streptococci and staphylococci were all inhibited by less than or equal to 6.3 micrograms/ml. Ciprofloxacin was 4- to 32-fold more active than norfloxacin and inhibited gentamicin-, ameikacin-, cefotaxime-, and moxalactam-resistant members of the family Enterobacteriaceae and P. aeruginosa and methicillin-resistant Staphylococcus aureus. The activity of ciprofloxacin was not affected by serum but decreased in the presence of acid urine. The frequency of resistance to ciprofloxacin was between 10(-7) and 10(-9).
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference9 articles.
1. In vitro activity of ciprofloxacin, norfloxacin, and nalidixic acid;Bauernfeind A.;Eur. J. Clin. Microbiol.,1983
2. In vitro antibacterial activity of AM-715, a new nalidixic acid analog;Ito A.;Antimicrob. Agents Chemother.,1980
3. Structure-activity relations of new ,B-lactam compounds and in vitro activity against common bacteria;Neu H. C.;Rev. Infect. Dis.,1983
4. In vitro activity of norfloxacin, a quinolone carboxylic acid, compared with that of f3-lactams, aminoglycosides, and trimethoprim;Neu H. C.;Antimicrob. Agents Chemother.,1982
5. A critical evaluation of nalidixic acid in urinary tract infections;Ronald A. R.;N. Engl. J. Med.,1956
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