Author:
Fuchs P C,Barry A L,Thornsberry C,Jones R N
Abstract
A total of 632 clinical bacterial isolates were tested for susceptibility to twofold dilutions of ticarcillin alone and in combination with 1, 2, and 4 micrograms of clavulanic acid (CA) (Timentin) per ml by a reference microdilution method. With the addition of CA, ticarcillin MICs were reduced eightfold or greater with 54 of 59 (92%) strains of the family Enterobacteriaceae with ticarcillin MICs of greater than or equal to 64 micrograms/ml. The inhibitory effect of CA on pseudomonads was minimal. Ticarcillin MICs for beta-lactamase-producing Haemophilus influenzae, Neisseria gonorrhoeae, and most Staphylococcus aureus were reduced to less than or equal to 0.5 micrograms/ml when CA was added. For dilution susceptibility testing of ticarcillin-clavulanic acid, dilutions of ticarcillin combined with 2 micrograms of CA per ml is suggested.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Pharmacokinetics and tissue penetration of ticarcillin combined with clavulanic acid;Bennett S.;Antimicrob. Agents Chemother.,1983
2. In vitro evaluation of Augmentin by broth microdilution and disk diffusion susceptibility testing: regression analysis, tentative interpretive criteria, and quality control limits;Fuchs P. C.;Antimicrob. Agents Chemother.,1983
3. Ticarcillin, carbenicillin and BL-P1908 in vitro comparison of three anti-pseudomonal semisynthetic penicillins;Fuchs P. C.;J. Antibiot.,1977
4. An in vitro evaluation of clavulanic acid, a potent, broad-spectrum betalactamase inhibitor;Greenwood D.;J. Antimicrob. Chemother.,1979
5. In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin;Hunter P. A.;J. Antimicrob. Chemother.,1980
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