Oral antiviral drugs in experimental herpes simplex keratitis

Author:

Kaufman H E,Varnell E D,Centifanto-Fitzgerald Y M,De Clercq E,Kissling G E

Abstract

Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice;De Clercq E.;Antimicrob. Agents Chemother.,1982

2. Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy;Field H. J.;Antimicrob. Agents Chemother.,1982

3. Gross A. J. and V. A. Clark. 1975. Survival distributions: reliability applications in the biomedical sciences. John Wiley & Sons Inc. New York.

4. Kaufman H. E. 1981. Local therapy of herpes simplex virus ocular infections p. 466-477. In A. J. Nahmias W. R. Dowdle and R. E. Schinazi (ed.) The human herpesviruses: an interdisciplinary perspective. Elsevier/ North-Holland Publishing Corp. New York.

5. Herpes simplex keratitis;Kaufman H. E.;Ophthalmology,1983

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